Nintena 100mg Capsule

Nintena 100mg Capsule contains Nintedanib 100 mg, a prescription medicine that belongs to the tyrosine kinase inhibitor (TKI) class. It is primarily used for the treatment of Idiopathic Pulmonary Fibrosis (IPF), Progressive Fibrosing Interstitial Lung Disease (PF-ILD), Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD), and in combination with chemotherapy for certain patients with Non-Small Cell Lung Cancer (NSCLC). The medicine helps slow disease progression by blocking proteins responsible for abnormal tissue scarring and tumour blood vessel formation.

Unlike medicines that only relieve symptoms, Nintena 100mg Capsule works at the cellular level to reduce fibrosis and limit disease progression. Regular treatment may help preserve lung function, improve breathing capacity, and delay worsening of chronic lung diseases when taken exactly as prescribed by a specialist.

For patients looking for similar prescription therapies, you can browse our Anti Cancer Medicines collection. You may also explore our Medicine Guide for expert-written health articles, medicine precautions, dosage advice, and disease awareness information.

• Treatment of Idiopathic Pulmonary Fibrosis (IPF).
• Treatment of Progressive Fibrosing Interstitial Lung Disease (PF-ILD).
• Treatment of Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD).
• Used with Docetaxel for advanced Non-Small Cell Lung Cancer (NSCLC) in eligible patients.
• Helps reduce progression of chronic fibrosing lung diseases.

• Helps slow the progression of Idiopathic Pulmonary Fibrosis (IPF).
• Reduces the rate of lung function decline.
• Helps delay worsening of Progressive Fibrosing Interstitial Lung Disease.
• Supports patients with Systemic Sclerosis-Associated ILD.
• Inhibits abnormal blood vessel growth in certain lung cancers.
• May improve long-term disease management when used consistently.
• Works by targeting multiple growth factor receptors involved in fibrosis and tumour growth.
• Can help preserve quality of life in chronic lung disease patients.

Common side effects include:

• Diarrhoea
• Nausea
• Vomiting
• Abdominal pain
• Decreased appetite
• Weight loss
• Liver enzyme elevation
• Fatigue
• Headache
• High blood pressure
• Mouth ulcers
• Indigestion

Serious side effects (seek immediate medical care):

• Severe liver injury
• Bleeding
• Blood clots
• Heart attack
• Gastrointestinal perforation
• Severe allergic reactions
• Persistent severe diarrhoea
• Yellowing of skin or eyes

• Take exactly as prescribed by your doctor.
• Always take with food.
• Swallow the capsule whole with water.
• Do not crush, chew, or open the capsule.
• Take it at the same time every day.
• Continue treatment unless your doctor advises stopping.
• Never adjust the dose yourself.

The dosage varies depending on the condition being treated, body weight, liver function, and overall health.

Usual Adult Dose

• One 100 mg capsule or as directed by the treating specialist.
• Dose adjustments may be required if side effects occur.
• Never exceed the prescribed dose.
• Follow all monitoring instructions during therapy.

Nintena 100mg Capsule contains Nintedanib, a multi-target tyrosine kinase inhibitor. It blocks several receptors, including VEGF, FGF, and PDGF receptors, which are involved in tissue fibrosis and abnormal blood vessel formation. By inhibiting these pathways, the medicine slows lung scarring in fibrotic lung diseases and helps reduce tumour growth in selected cancer patients.

• Prescription Medicine: Use only under medical supervision.
• Pregnancy: May harm an unborn baby. Avoid use during pregnancy unless specifically prescribed.
• Breastfeeding: Breastfeeding is generally not recommended during treatment.
• Liver Disease: Use with caution. Regular liver function tests are recommended.
• Kidney Disease: Use only as advised by your doctor.
• Heart Disease: Inform your doctor if you have a history of heart attack, stroke, or blood clots.
• Bleeding Disorders: Use cautiously, especially if taking blood-thinning medicines.
• Surgery: Inform your surgeon before any planned operation, as temporary interruption of treatment may be required.
• Driving: If you experience dizziness or fatigue, avoid driving or operating heavy machinery.
• Alcohol: Excessive alcohol intake should be avoided as it may increase the risk of liver-related side effects.
• Monitoring: Regular blood tests, liver function tests, and blood pressure checks are recommended throughout treatment.

• Take the missed dose as soon as you remember.
• If it is almost time for the next dose, skip the missed dose.
• Do not take two doses together.
• Continue with your regular schedule.
• Contact your doctor if multiple doses are missed.

(Substitutes should only be taken after consulting your doctor.)

• Nindanib 100 Capsule
• Nintedanib 100 mg Capsules (other approved brands)
• Ofev 100 mg Soft Capsule (where available)

• Take the medicine at the same time every day.
• Swallow the capsule whole with water.
• Do not crush, chew, or open the capsule.
• Take it with meals to reduce stomach upset.
• Do not miss scheduled blood tests and liver function monitoring.
• Monitor blood pressure regularly if advised by your doctor.
• Stay well hydrated, especially if diarrhoea occurs.
• Avoid self-medication while taking Nintena.
• Inform your doctor immediately if you experience severe abdominal pain, chest pain, breathing difficulty, unusual bleeding, or vision changes.
• Continue treatment only for the duration recommended by your specialist.

• Generic Name: Nintedanib
• Strength: 100 mg
• Dosage Form: Capsule
• Brand: Nintena
• Manufacturer: Mankind Pharma Ltd
• Prescription Required: Yes
• Medicine Class: Tyrosine Kinase Inhibitor (TKI)
• Route of Administration: Oral
• Common Uses: Idiopathic Pulmonary Fibrosis (IPF), Progressive Fibrosing ILD, Systemic Sclerosis-Associated ILD, and selected cases of Non-Small Cell Lung Cancer (NSCLC)
• Habit Forming: No
• Storage Temperature: Below 30°C
• Suitable for Children: Only if specifically prescribed by a specialist (not routinely recommended)
• Pregnancy: Not recommended unless clearly advised by a doctor
• Breastfeeding: Generally not recommended during treatment

Nintena 100mg Capsule may interact with the following medicines:

Medicines that may increase Nintedanib levels

• Ketoconazole
• Itraconazole
• Erythromycin
• Clarithromycin
• Cyclosporine

Medicines that may reduce its effectiveness

• Rifampicin
• Carbamazepine
• Phenytoin
• Phenobarbital
• St. John's Wort

Blood thinners (higher bleeding risk)

• Warfarin
• Apixaban
• Rivaroxaban
• Dabigatran
• Heparin
• Aspirin
• Clopidogrel

Other Important Interactions

• Anti-inflammatory medicines (NSAIDs)
• Certain chemotherapy medicines
• Herbal supplements
• Vitamin supplements taken without medical advice

Always provide your doctor with a complete list of prescription medicines, over-the-counter medicines, vitamins, and herbal supplements before starting treatment.

Patients taking Nintena 100mg Capsule often have questions about treatment duration, side effects, and daily precautions. This medicine works best when taken consistently under the supervision of a specialist.

• Take the capsule exactly as prescribed and do not skip doses.
• Always take it with food to reduce stomach-related side effects.
• Diarrhoea is common during treatment. Drink plenty of fluids and inform your doctor if it becomes severe or persistent.
• Routine liver function tests and blood pressure monitoring are usually required during treatment.
• Inform your doctor if you notice yellowing of the eyes or skin, dark urine, severe stomach pain, unusual bruising, or bleeding.
• Avoid smoking whenever possible, as it may reduce treatment effectiveness and worsen lung disease.
• Women of childbearing age should use effective contraception during treatment and for the period recommended by their doctor after the last dose.
• Tell your healthcare provider about any planned surgery or dental procedure before treatment.
• Maintain regular follow-up appointments so your doctor can monitor your response and adjust the dose if required.
• Never stop taking Nintena 100mg Capsule without medical advice, even if your symptoms improve.

1. What is Nintena 100mg Capsule used for?

It is used to treat Idiopathic Pulmonary Fibrosis, Progressive Fibrosing ILD, Systemic Sclerosis-Associated ILD, and certain cases of Non-Small Cell Lung Cancer.

2. Can I take it without food?

No. It should be taken with food to reduce stomach-related side effects.

3. Is it chemotherapy?

No. It is a targeted therapy known as a tyrosine kinase inhibitor.

4. Can it cure pulmonary fibrosis?

No. It does not cure the disease but helps slow its progression.

5. Can diarrhoea occur during treatment?

Yes. Diarrhoea is one of the most common side effects. Stay hydrated and contact your doctor if it becomes severe.

6. Is regular blood testing required?

Yes. Your doctor may monitor liver function, blood pressure, and overall health during treatment.

Active Ingredient

• Nintedanib 100 mg

Inactive Ingredients

May include pharmaceutical excipients such as:

• Capsule shell
• Microcrystalline cellulose
• Magnesium stearate
• Colloidal silicon dioxide
• Other approved inactive ingredients

• Store below 30°C.
• Keep away from direct sunlight.
• Protect from moisture.
• Store in the original blister pack.
• Keep out of reach of children and pets.
• Do not use after the expiry date.