Mikastar 500 Injection

Mikastar 500 Injection

Mikastar 500 Injection contains Amikacin Sulphate 500 mg, a prescription aminoglycoside antibiotic used to treat a wide range of serious bacterial infections. It is commonly prescribed when infections are caused by bacteria that do not respond well to other antibiotics. The medicine works by stopping bacterial protein synthesis, preventing the bacteria from multiplying and helping the body eliminate the infection.

This injection is used in hospitals and healthcare settings for the treatment of infections involving the lungs, urinary tract, bloodstream, abdomen, bones, joints, skin, soft tissues, and other organs. It is also used in combination with other antibiotics for severe or life-threatening bacterial infections.

Mikastar 500 Injection is effective only against bacterial infections and should not be used for viral illnesses such as the common cold or influenza. Since improper use of antibiotics can contribute to antibiotic resistance, this medicine should always be taken exactly as prescribed by a qualified healthcare professional.

Patients receiving this medicine may require regular monitoring of kidney function, hearing ability, and blood levels of the medicine, especially during prolonged treatment or in individuals with kidney disease.

For more prescription medicines, visit our Prescription Medicines collection.

You can also explore our complete range of Antibiotic Medicines for doctor-prescribed bacterial infection treatments.

For trusted medical information about antibiotics and bacterial infections, visit MedlinePlus – Antibiotics and CDC – Antibiotic Use.

Key Highlights

• Contains Amikacin Sulphate 500 mg.
• Belongs to the aminoglycoside antibiotic class.
• Used for serious bacterial infections.
• Given only under medical supervision.
• Not effective against viral infections.
• Requires prescription from a registered medical practitioner.
• Kidney function and hearing may require monitoring during treatment.

Mikastar 500 Injection is commonly prescribed for the treatment of:

• Severe bacterial lung infections
• Pneumonia
• Urinary tract infections (UTIs)
• Kidney infections
• Bloodstream infections (Septicemia)
• Skin and soft tissue infections
• Bone infections
• Joint infections
• Intra-abdominal infections
• Post-surgical bacterial infections
• Hospital-acquired bacterial infections
• Serious infections caused by Gram-negative bacteria
• Mixed bacterial infections (with combination therapy)
• Other susceptible bacterial infections as determined by the treating physician

• Helps eliminate serious bacterial infections effectively.
• Stops the growth and multiplication of harmful bacteria.
• Provides rapid antibacterial action when given by injection.
• Useful in treating complicated urinary tract infections.
• Helps manage severe respiratory tract infections.
• Effective against bloodstream infections (septicemia).
• Used for abdominal and gastrointestinal bacterial infections.
• Helps treat skin and soft tissue infections.
• Useful in treating bone and joint infections.
• Often prescribed for hospital-acquired infections.
• Can be used in combination with other antibiotics for severe infections.
• Helps reduce complications caused by untreated bacterial infections.
• Trusted aminoglycoside antibiotic with broad-spectrum activity.
• Suitable for use only under professional medical supervision.

Like all prescription medicines, Mikastar 500 Injection (Amikacin Sulphate 500 mg) may cause side effects in some patients. Most side effects are mild and temporary, but certain reactions require immediate medical attention.

Common Side Effects

• Pain, redness, or swelling at the injection site
• Nausea
• Vomiting
• Mild fever
• Headache
• Skin rash
• Dizziness
• Weakness
• Loss of appetite

• Less Common Side Effects

• Increased thirst
• Changes in urination
• Muscle twitching
• Ringing in the ears (Tinnitus)
• Temporary hearing changes
• Mild allergic skin reactions

• Serious Side Effects (Seek Immediate Medical Attention)

• Difficulty breathing
• Swelling of the face, lips, tongue, or throat
• Severe allergic reaction (Anaphylaxis)
• Hearing loss or persistent ringing in the ears
• Decreased urine output
• Kidney damage
• Muscle weakness or breathing difficulty due to nerve-muscle blockage
• Severe skin reactions
• Contact your doctor immediately if you notice signs of kidney problems, hearing changes, or severe allergic reactions during treatment.

• Mikastar 500 Injection should only be administered by a qualified doctor or trained healthcare professional.
• It is given either as an intravenous (IV) infusion or intramuscular (IM) injection, depending on your medical condition.
• Never attempt to self-administer this injection at home unless specifically instructed by your healthcare provider.
• The dose and duration of treatment depend on the type and severity of infection, age, body weight, and kidney function.
• Complete the full prescribed course even if you start feeling better before treatment ends.
• Missing doses or stopping treatment early may increase the risk of antibiotic resistance and recurrence of infection.

• Always use Mikastar 500 Injection exactly as prescribed by your doctor.
• The dosage is individualized based on body weight, age, infection severity, and kidney function.
• Adults generally receive one or more doses daily according to the physician's recommendation.
• Children receive weight-based dosing under pediatric supervision.
• Patients with reduced kidney function require dosage adjustment.
• Never increase, decrease, or skip doses without medical advice.

Mikastar 500 Injection contains Amikacin, an aminoglycoside antibiotic that works by attaching to the 30S ribosomal subunit of bacteria. This action blocks bacterial protein synthesis, preventing the bacteria from producing essential proteins required for growth and survival.

Without these proteins, bacteria cannot multiply and eventually die, allowing the body's immune system to clear the infection. Amikacin is particularly effective against many Gram-negative bacteria and is often reserved for serious or hospital-acquired infections where other antibiotics may not be effective.

It is important to note that Mikastar 500 Injection is effective only against bacterial infections and has no effect on viral illnesses such as the common cold or flu.

Pregnancy

Use during pregnancy only if clearly needed and prescribed by a doctor. Aminoglycoside antibiotics may pose a risk to the developing baby.

Breastfeeding

Amikacin passes into breast milk in very small amounts. Consult your doctor before breastfeeding while receiving this medicine.

Kidney Disease

Use with caution. Patients with kidney impairment require dose adjustments and regular kidney function monitoring.

Liver Disease

Generally considered safe, but use under medical supervision.

Elderly Patients

Older adults may have an increased risk of kidney and hearing-related side effects. Regular monitoring is recommended.

Children

Can be prescribed in children and newborns only under specialist supervision with appropriate dose adjustments.

Driving and Operating Machinery

This medicine may cause dizziness in some individuals. Avoid driving or operating heavy machinery if you feel dizzy.

Alcohol

No direct interaction is known, but avoiding alcohol during treatment is advisable to support recovery and reduce unnecessary strain on the body.

Allergy

Do not use this medicine if you are allergic to Amikacin or any other aminoglycoside antibiotics such as Gentamicin or Tobramycin.

Since Mikastar 500 Injection is generally administered by a doctor or trained healthcare professional in a hospital or clinic, the chances of missing a dose are very low.

• If you think a scheduled dose has been missed, inform your doctor or nurse immediately.
• Do not take a double dose to make up for the missed one.
• The treatment schedule may be adjusted by your healthcare provider depending on your condition.
• Completing the full course of treatment is important, even if your symptoms improve earlier.
• Missing multiple doses may reduce the effectiveness of the antibiotic and increase the risk of antibiotic resistance.

The following medicines contain Amikacin Injection as the active ingredient and may be considered alternatives if recommended by your doctor or pharmacist:

• Amikacin Injection IP 500 mg
• Amikin 500 Injection
• Amipara 500 Injection
• Amikacin Sulphate Injection IP 500 mg (various manufacturers)
• Amifresh 500 Injection
• Amikacure 500 Injection

Note: Never switch to a substitute without consulting your doctor. Different manufacturers may have variations in formulation, packaging, or pricing.

• Use this medicine only on the advice of a registered healthcare professional.
• Complete the full prescribed course even if symptoms improve.
• Drink adequate water unless your doctor advises otherwise.
• Inform your doctor about any kidney disease or hearing problems before starting treatment.
• Attend all follow-up appointments for kidney function and hearing tests if advised.
• Do not share this medicine with anyone else.
• Avoid unnecessary use of antibiotics to reduce the risk of antibiotic resistance.
• Inform your healthcare provider about all medicines and supplements you are taking.
• Report any hearing changes, ringing in the ears, or decreased urine output immediately.
• Keep all medicines out of the reach of children.

• Medicine Type: Prescription Antibiotic
• Drug Class: Aminoglycoside Antibiotic
• Generic Name: Amikacin Sulphate
• Strength: 500 mg
• Dosage Form: Injection
• Route of Administration: Intramuscular (IM) or Intravenous (IV)
• Prescription Required: Yes
• Suitable For: Adults and children (under medical supervision)
• Effective Against: Serious bacterial infections
• Not Effective Against: Viral infections such as the common cold or flu
• Manufacturer: Mankind Pharma Ltd.
• Storage Temperature: Below 25°C

Mikastar 500 Injection may interact with certain medicines, increasing the risk of side effects or reducing treatment effectiveness. Inform your doctor if you are taking:

Medicines That May Increase Kidney Damage

• Vancomycin
• Colistin
• Amphotericin B
• Cisplatin
• Cyclosporine
• Tacrolimus

Medicines That May Increase Hearing Problems

• Furosemide
• Ethacrynic Acid

Neuromuscular Blocking Agents

• Succinylcholine
• Rocuronium
• Vecuronium

Other Antibiotics

• Piperacillin
• Cephalosporins
• Penicillins (depending on administration conditions)

Always provide your doctor with a complete list of prescription medicines, over-the-counter drugs, vitamins, and herbal supplements before starting treatment.
 

I have kidney disease. Can I receive Mikastar 500 Injection?

Yes, but only under close medical supervision. Dose adjustments and regular kidney function tests may be required.

I noticed ringing in my ears after starting treatment.

Stop using the medicine and contact your doctor immediately, as this could indicate hearing-related side effects.

Can I stop treatment once I feel better?

No. Always complete the full prescribed course to ensure the infection is completely treated and to help prevent antibiotic resistance.

Can this medicine treat viral fever or the common cold?

No. Mikastar 500 Injection works only against bacterial infections.

Is hospitalization necessary?

Many patients receive this medicine in hospitals, but in some cases it may also be administered in an outpatient setting under medical supervision.

1. What is Mikastar 500 Injection used for?

It is used to treat serious bacterial infections affecting different parts of the body, including the lungs, urinary tract, skin, blood, bones, and abdomen.

2. Is Mikastar 500 Injection an antibiotic?

Yes. It belongs to the aminoglycoside class of antibiotics.

3. Can I take this injection at home?

It should only be administered by a qualified healthcare professional unless your doctor specifically advises otherwise.

4. Does it work for viral infections?

No. It is effective only against bacterial infections.

5. Can it affect my kidneys?

Yes. Kidney function may be affected, especially with prolonged use or in patients with pre-existing kidney disease. Regular monitoring is recommended.

6. Can it cause hearing problems?

Yes. Hearing changes or ringing in the ears may occur in some patients. Inform your doctor immediately if you experience these symptoms.

Active Ingredient

• Amikacin Sulphate equivalent to Amikacin 500 mg

Other Ingredients

The injection also contains pharmaceutical-grade inactive ingredients required for formulation stability, sterility, and safe administration. The complete list of excipients may vary slightly depending on the manufacturing batch.

• Store below 25°C in a cool and dry place.
• Protect from direct sunlight and excessive heat.
• Do not freeze the injection.
• Keep the vial in its original packaging until use.
• Keep out of reach of children and pets.
• Do not use if the solution appears discolored or contains visible particles.
• Discard any unused portion as advised by your healthcare provider.