Panimun Bioral 50mg Capsule

Panimun Bioral 50mg Capsule is a prescription medicine containing Cyclosporine, a calcineurin inhibitor that suppresses the body's immune response. It is primarily prescribed to prevent rejection following kidney, liver, or heart transplantation by reducing immune system activity.

Apart from transplant medicine, Panimun Bioral is also indicated for the management of severe autoimmune diseases including rheumatoid arthritis, psoriasis, nephrotic syndrome, and certain inflammatory eye disorders when other treatments have not produced satisfactory results.

This medicine should only be taken under the supervision of a qualified healthcare professional. Regular monitoring of kidney function, liver function, blood pressure, and blood cyclosporine levels may be required during treatment to ensure safety and effectiveness.

Do not stop or change the dose without consulting your doctor, as sudden discontinuation may increase the risk of transplant rejection or worsening of the underlying disease.

Panimun Bioral 50mg Capsule is used for:

• Prevention of kidney transplant rejection.
• Prevention of liver transplant rejection.
• Prevention of heart transplant rejection.
• Severe rheumatoid arthritis.
• Severe plaque psoriasis.
• Nephrotic syndrome.
• Certain autoimmune eye diseases (uveitis).
• Other autoimmune disorders as prescribed by the physician.

• Helps prevent rejection after organ transplantation.
• Suppresses abnormal immune system activity.
• Reduces inflammation associated with autoimmune diseases.
• Improves symptoms of severe rheumatoid arthritis.
• Effective in controlling severe psoriasis.
• Helps manage nephrotic syndrome.
• Reduces flare-ups in immune-mediated conditions.
• Supports long-term transplant success under medical supervision.

Common side effects may include:

• Headache
• Tremors
• Increased blood pressure
• Nausea
• Vomiting
• Diarrhea
• Increased hair growth
• Gum swelling (gingival hyperplasia)
• Increased risk of infections
• Kidney function abnormalities
• Elevated liver enzymes
• Increased blood sugar
• Fatigue
• Muscle cramps
• Seek immediate medical attention if severe allergic reactions, persistent fever, reduced urine output, severe swelling, or unusual bleeding occur.

• Take exactly as prescribed by your doctor.
• Swallow the capsule whole with water.
• Do not crush, chew, or open the capsule.
• Take it at the same time every day.
• Maintain a consistent schedule regarding meals.
• Avoid grapefruit and grapefruit juice during treatment.
• Continue treatment even if you feel well unless instructed otherwise.

The dosage depends upon:

• Body weight
• Medical condition
• Organ transplant type
• Blood cyclosporine concentration
• Response to treatment

Always follow your doctor's prescribed dosage. Never alter the dose on your own.

Cyclosporine inhibits calcineurin, preventing activation of T-lymphocytes responsible for immune responses. By suppressing these immune cells, it reduces the body's tendency to attack transplanted organs and decreases inflammation in autoimmune diseases.

• Prescription-only medicine.
• Use only under specialist supervision.
• Regular blood tests may be required.
• Kidney and liver function should be monitored.
• Blood pressure monitoring is recommended.
• Avoid live vaccines during treatment.
• Avoid close contact with people having contagious infections.
• Inform your doctor about all medicines you are taking.
• Use during pregnancy only if clearly advised.
• Breastfeeding is generally not recommended while taking cyclosporine.

• Take the missed dose as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose.
• Do not double the dose.
• Continue your regular dosing schedule.

Possible substitutes (only if prescribed by a physician):

• Cyclophil ME 50 Capsule
• Cyclopan 50 Capsule
• Imusporin 50 Capsule
• Neoral 50mg Capsule
• Ecosporin/Cyclosporine 50mg brands available in India

Never switch brands without your doctor's advice, as different formulations may not be bioequivalent.

• Take the medicine consistently every day.
• Attend all follow-up appointments.
• Regular blood monitoring is essential.
• Monitor blood pressure regularly.
• Stay hydrated.
• Avoid alcohol unless approved by your doctor.
• Avoid grapefruit products.
• Inform healthcare providers before surgery.
• Report signs of infection immediately.
• Do not discontinue treatment abruptly.

• Generic Name: Cyclosporine
• Strength: 50 mg
• Drug Class: Calcineurin Inhibitor
• Dosage Form: Soft Gelatin Capsule
• Route: Oral
• Prescription Required: Yes
• Suitable for transplant recipients and selected autoimmune disorders
• Long-term monitoring is necessary during therapy

Cyclosporine may interact with:

• Tacrolimus
• Sirolimus
• Ketoconazole
• Fluconazole
• Rifampicin
• Erythromycin
• Clarithromycin
• Diltiazem
• Verapamil
• Phenytoin
• Carbamazepine
• NSAIDs
• Potassium supplements
• Potassium-sparing diuretics
• Live vaccines
• Grapefruit juice
• Always inform your doctor about all prescription medicines, supplements, and herbal products.

Patients taking Panimun Bioral should:

• Never miss follow-up appointments.
• Take medicine exactly as prescribed.
• Watch for signs of infection.
• Maintain good oral hygiene to reduce gum swelling.
• Monitor blood pressure regularly.
• Avoid smoking and excessive alcohol.
• Follow dietary advice given by the physician.
• Inform the doctor if pregnancy is planned.
• Avoid self-medication.

1. What is Panimun Bioral 50mg Capsule used for?

It is used to prevent organ transplant rejection and treat certain autoimmune disorders.

2. Is Panimun Bioral a steroid?

No. It is an immunosuppressant medicine and not a steroid.

3. Can I stop taking it suddenly?

No. Stopping suddenly may lead to transplant rejection or worsening of the disease.

4. Why are regular blood tests necessary?

Blood tests monitor cyclosporine levels and help detect kidney, liver, or blood-related side effects early.

5. Can I take it with food?

Yes, but take it consistently either with or without food as advised by your doctor.

6. Can I drink grapefruit juice?

No. Grapefruit can significantly increase cyclosporine levels and increase side effects.

7. Does it increase infection risk?

Yes. Since it suppresses the immune system, infections may occur more easily.

8. Is it safe during pregnancy?

Use only if prescribed after careful evaluation of risks and benefits.

Each soft gelatin capsule contains:

• Cyclosporine IP 50 mg

Inactive ingredients may include approved pharmaceutical excipients used for capsule formulation.

• Store below 25°C.
• Keep away from moisture and direct sunlight.
• Store in the original packaging.
• Keep out of reach of children.
• Do not use after the expiry date.